The reporter said on Instagram that she was morally "not aligned" with Disney's COVID-19 vaccine mandate.
The Brooklyn Nets guard was suspended by the team for vaccine refusal that would limit him to less than half of the games.
The anchor was criticized for calling her company's vaccine mandate "sick" and questioning Barack Obama's Blackness.
The sports network's longtime commentator said she got the shot mandated by her employer, but feels "defeated."
The former New York Giants quarterback was talking about young Philadelphia fans when the ESPN broadcast took an off-color turn.
Iowa State fans hadn't forgotten the actor's remarks on how little he bathes.
"After a lot of prayer and deliberation, I have decided I must put my family and personal health first," said Williams, who is trying to have a second child.
The sports reporter and ESPN had been unable to agree on a new contract. She also left the channel after news emerged of a colleague's racist remarks.
The "NBA Countdown" host and the network were unable to reach an agreement on an extension of her contract, which expired this week.
The ESPN host said Angels superstar Shohei Ohtani's use of an interpreter for media appearances "contributes to harming" Major League Baseball.